|
| Player | Team | OPP | Comp | Att | Yds | TD | Int | FP |
| Philip Rivers | SD | WAS | 28 | 38 | 350 | 3 | 1 | 30 |
| Donovan McNabb | PHI | DAL | 31 | 42 | 323 | 3 | 1 | 29 |
| Ben Roethlisberger | PIT | MIA | 28 | 42 | 353 | 3 | 2 | 28 |
| Tom Brady | NE | HOU | 28 | 38 | 281 | 3 | 1 | 27 |
| Matt Schaub | HOU | NE | 25 | 37 | 300 | 3 | 2 | 26 |
| Joe Flacco | BAL | OAK | 25 | 35 | 291 | 2 | 0 | 24 |
| Kurt Warner | ARI | GB | 28 | 39 | 324 | 2 | 1 | 23 |
| Eli Manning | NYG | MIN | 26 | 37 | 307 | 2 | 1 | 22 |
| Alex Smith | SF | STL | 27 | 36 | 238 | 2 | 0 | 22 |
| Jay Cutler | CHI | DET | 24 | 31 | 217 | 2 | 0 | 21 |
| David Garrard | JAC | CLE | 25 | 34 | 231 | 2 | 0 | 21 |
| Kyle Orton | DEN | KC | 23 | 29 | 223 | 2 | 0 | 21 |
| Vince Young | TEN | SEA | 23 | 34 | 255 | 2 | 1 | 20 |
| Matt Ryan | ATL | TB | 24 | 33 | 274 | 2 | 2 | 19 |
| Tony Romo | DAL | PHI | 26 | 37 | 281 | 2 | 2 | 19 |
| Josh Freeman | TB | ATL | 22 | 34 | 231 | 2 | 2 | 17 |
| Carson Palmer | CIN | NYJ | 24 | 38 | 308 | 1 | 1 | 16 |
| Matt Cassel | KC | DEN | 22 | 32 | 237 | 2 | 3 | 15 |
| Brett Favre | MIN | NYG | 24 | 33 | 267 | 1 | 1 | 15 |
| Jason Campbell | WAS | SD | 20 | 34 | 265 | 1 | 1 | 15 |
| Matt Moore | CAR | NO | 21 | 34 | 224 | 1 | 1 | 13 |
| Chad Henne | MIA | PIT | 16 | 28 | 193 | 1 | 1 | 12 |
| Mark Brunell | NO | CAR | 16 | 26 | 202 | 1 | 1 | 12 |
| Mark Sanchez | NYJ | CIN | 24 | 32 | 218 | 1 | 2 | 11 |
| Derek Anderson | CLE | JAC | 17 | 28 | 151 | 1 | 2 | 8 |
| Matt Hasslebeck | SEA | TEN | 20 | 34 | 197 | 1 | 3 | 8 |
| Ryan Fitzpatrick | BUF | IND | 17 | 31 | 223 | 0 | 2 | 5 |
| Keith Null | STL | SF | 16 | 31 | 211 | 0 | 2 | 4 |
| Charlie Frye | OAK | BAL | 14 | 29 | 197 | 0 | 2 | 4 |
| Peyton Manning | IND | BUF | 3 | 4 | 42 | 0 | 0 | 2 |
| Daunte Culpepper | DET | CHI | 15 | 28 | 179 | 0 | 3 | 1 |
| Aaron Rodgers | GB | ARI | 2 | 3 | 25 | 0 | 0 | 1 |
|
|