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| Player | Team | OPP | Att | Rush Yds | Rush TD | Rec | Rec Yds | Rec TD | FP |
| Chris Johnson | TEN | SEA | 24 | 167 | 2 | 5 | 42 | 0 | 33 |
| Maurice Jones-Drew | JAC | CLE | 23 | 106 | 2 | 4 | 44 | 0 | 27 |
| Matt Forte | CHI | DET | 23 | 147 | 1 | 3 | 57 | 0 | 26 |
| Ray Rice | BAL | OAK | 21 | 159 | 1 | 3 | 31 | 0 | 25 |
| Jonathan Stewart | CAR | NO | 22 | 103 | 2 | 1 | 15 | 0 | 24 |
| Frank Gore | SF | STL | 18 | 129 | 1 | 3 | 29 | 0 | 22 |
| Cedric Benson | CIN | NYJ | 22 | 131 | 1 | 2 | 14 | 0 | 21 |
| Adrian Peterson | MIN | NYG | 21 | 95 | 1 | 4 | 37 | 0 | 19 |
| Thomas Jones | NYJ | CIN | 25 | 115 | 1 | 3 | 19 | 0 | 19 |
| Jamaal Charles | KC | DEN | 17 | 88 | 1 | 4 | 28 | 0 | 18 |
| Donald Brown | IND | BUF | 15 | 63 | 1 | 4 | 58 | 0 | 18 |
| Jerome Harrison | CLE | JAC | 17 | 90 | 1 | 3 | 29 | 0 | 18 |
| Knowshon Moreno | DEN | KC | 19 | 78 | 1 | 2 | 19 | 0 | 16 |
| Mike Bell | NO | CAR | 16 | 77 | 1 | 2 | 20 | 0 | 16 |
| Ahmad Bradshaw | NYG | MIN | 15 | 71 | 1 | 3 | 29 | 0 | 16 |
| Laurence Maroney | NE | HOU | 16 | 72 | 1 | 2 | 13 | 0 | 15 |
| Jason Snelling | ATL | TB | 18 | 86 | 1 | 1 | 7 | 0 | 15 |
| Brandon Jackson | GB | ARI | 16 | 67 | 1 | 2 | 23 | 0 | 15 |
| Rashard Mendenhall | PIT | MIA | 17 | 73 | 1 | 2 | 16 | 0 | 15 |
| Steven Jackson | STL | SF | 22 | 90 | 0 | 4 | 53 | 0 | 14 |
| Ryan Moats | HOU | NE | 11 | 44 | 1 | 2 | 24 | 0 | 13 |
| Reggie Bush | NO | CAR | 3 | 12 | 1 | 4 | 52 | 0 | 12 |
| Correll Buckhalter | DEN | KC | 11 | 56 | 1 | 0 | 0 | 0 | 12 |
| Derrick Ward | TB | ATL | 7 | 32 | 1 | 2 | 18 | 0 | 11 |
| Lex Hilliard | MIA | PIT | 11 | 47 | 1 | 0 | 0 | 0 | 11 |
| Tim Hightower | ARI | GB | 7 | 34 | 0 | 5 | 62 | 0 | 10 |
| Cadillac Williams | TB | ATL | 15 | 63 | 0 | 3 | 32 | 0 | 10 |
| Maurice Morris | DET | CHI | 17 | 73 | 0 | 2 | 27 | 0 | 10 |
| Marion Barber III | DAL | PHI | 12 | 48 | 0 | 3 | 39 | 0 | 9 |
| Fred Jackson | BUF | IND | 16 | 67 | 0 | 2 | 19 | 0 | 9 |
| Chris Wells | ARI | GB | 16 | 77 | 0 | 2 | 14 | 0 | 9 |
| Felix Jones | DAL | PHI | 7 | 38 | 0 | 2 | 46 | 0 | 8 |
| Quinton Gather | WAS | SD | 13 | 57 | 0 | 3 | 23 | 0 | 8 |
| LaDainian Tomlinson | SD | WAS | 14 | 59 | 0 | 3 | 21 | 0 | 8 |
| Julius Jones | SEA | TEN | 12 | 53 | 0 | 3 | 13 | 0 | 7 |
| Marshawn Lynch | BUF | IND | 6 | 25 | 0 | 3 | 41 | 0 | 7 |
| Justin Forsett | SEA | TEN | 7 | 29 | 0 | 2 | 29 | 0 | 6 |
| Jerious Norwood | ATL | TB | 5 | 24 | 0 | 3 | 32 | 0 | 6 |
| Kevin Faulk | NE | HOU | 2 | 10 | 0 | 3 | 51 | 0 | 6 |
| Brian Westbrook | PHI | DAL | 4 | 18 | 0 | 2 | 37 | 0 | 5 |
| Darren McFadden | OAK | BAL | 7 | 33 | 0 | 2 | 21 | 0 | 5 |
| Ryan Grant | GB | ARI | 5 | 21 | 0 | 3 | 29 | 0 | 5 |
| LeSean McCoy | PHI | DAL | 9 | 37 | 0 | 1 | 11 | 0 | 5 |
| Chester Taylor | MIN | NYG | 3 | 14 | 0 | 2 | 24 | 0 | 4 |
| Kenneth Darby | STL | SF | 3 | 12 | 0 | 2 | 21 | 0 | 3 |
| Sammy Morris | NE | HOU | 0 | 0 | 0 | 2 | 27 | 0 | 3 |
| Lynell Hamilton | NO | CAR | 7 | 27 | 0 | 0 | 0 | 0 | 3 |
| Michael Bush | OAK | BAL | 6 | 25 | 0 | 1 | 4 | 0 | 3 |
| Shonn Greene | NYJ | CIN | 6 | 31 | 0 | 0 | 0 | 0 | 3 |
| Rock Cartwright | WAS | SD | 2 | 9 | 0 | 1 | 22 | 0 | 3 |
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